A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20750 |
| Swiss-prot Accession number | P43140 (Sequence in FASTA format) |
| Description | Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha 1A-adrenoreceptor) (Alpha-1C adrenergic receptor). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Abundant in heart, brain, aorta, vena cava, vas deferens, submaxillary gland, lung, and kidney. Found at lower levels in prostate, parotid gland and skeletal muscle. |
| Post translational modification | Carboxyl-terminal Ser or Thr residues may be phosphorylated (By similarity). |
| Function | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. |
| Protein Length | 466 Amino acids |
| Molecular weight | 51598 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 7923624 2 PubMed abstract 7935320 3 PubMed abstract 8185565 |
| Hormone | N/A |
| Gene ID | 29412 |
| PDB ID | 2F75 |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |