A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20780 |
| Swiss-prot Accession number | P08588 (Sequence in FASTA format) |
| Description | Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1adrenoreceptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein. Note=Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. |
| Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. |
| Protein Length | 477 Amino acids |
| Molecular weight | 51323 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 2825170 2 PubMed abstract 10477438 3 Rieder M.J., Daniels R.L., da Ponte S.H., Hastings N.C., Ahearn M.O.,Rajkumar N., Yi Q., Nickerson D.A.; "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 15358775 5 PubMed abstract 10212248 6 PubMed abstract 11052857 7 PubMed abstract 11854867 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |