A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20794 |
| Swiss-prot Accession number | Q8UUY8 (Sequence in FASTA format) |
| Description | Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). |
| Source organism | Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei;Protacanthopterygii; Salmoniformes; Salmonidae; Oncorhynchus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Highly expressed in the liver and red and white muscle, with lower levels of expression in the gills, heart, kidney and spleen. |
| Post translational modification | Lacks the regulatory protein kinase A phosphorylation sites within the G-protein binding domain that mediate desensitization and are present in mammalian homologs. |
| Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity). |
| Protein Length | 409 Amino acids |
| Molecular weight | 45098 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 11737201 |
| Hormone | N/A |
| Gene ID | 100136153 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |