A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20930 |
| Swiss-prot Accession number | Q9TUK4 (Sequence in FASTA format) |
| Description | Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropinreceptor) (Melanocortin receptor 1) (MC1-R). |
| Source organism | Pan troglodytes (Chimpanzee) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Pan. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). |
| Protein Length | 317 Amino acids |
| Molecular weight | 34700 |
| Domain Name | 7tm_1 |
| References | 1 Rees J.L., Harding R.M., Healy E., Jackson I.J., Ray A.J., Ellis N.S.,Flanagan N., Todd C., Dixon C., Matthews J.N., Sajantila A.,Birch-MacHin M.A.; "Chimpanzee melanocortin 1 sequence."; Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 12687585 3 Nakayama K., Shotake T., Takenaka O., Ishida T.; "Variation of the melanocortin 1 receptor gene in the macaques."; Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. 4 Rees J.L., Harding R.M., Healy E., Jackson I.J., Ray A.J., Ellis N.S.,Flanagan N., Todd C., Dixon C., Matthews J.N., Sajantila A.,Birch-MacHin M.A.; "Chimpanzee melanocortin 1 sequence."; Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 12687585 6 Nakayama K., Shotake T., Takenaka O., Ishida T.; "Variation of the melanocortin 1 receptor gene in the macaques."; Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. |
| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |