A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20975 |
| Swiss-prot Accession number | O46561 (Sequence in FASTA format) |
| Description | Prolactin receptor precursor (PRL-R) (OPR). |
| Source organism | Ovis aries (Sheep) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis. |
| Subcellular location | Membrane; Single-pass type I membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains. |
| Tissue Specificity | Expressed in all tissues examined; liver, pituitary, adrenal gland, ovary and fetal liver. |
| Post translational modification | N/A |
| Function | This is a receptor for the anterior pituitary hormone prolactin. |
| Protein Length | 581 Amino acids |
| Molecular weight | 65235 |
| Domain Name | fn3 |
| References | 1 PubMed abstract 9343303 2 PubMed abstract 9832462 3 Anthony R.V., Smith G.W., Duong A., Pratt S.L., Smith M.F.; "Two forms of the prolactin receptor messenger ribonucleic acid arepresent in ovine fetal liver and adult ovary."; Endocrine 3:291-295(1995). |
| Hormone | P01240 Detail in HMRbase |
| Gene ID | 443020 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |