A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20999 |
| Swiss-prot Accession number | P25117 (Sequence in FASTA format) |
| Description | Calcitonin receptor precursor (CT-R). |
| Source organism | Sus scrofa (Pig) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells. |
| Protein Length | 498 Amino acids |
| Molecular weight | 57155 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 1658940 2 PubMed abstract 8034723 3 PubMed abstract 1658940 4 PubMed abstract 8034723 |
| Hormone | P01259 Detail in HMRbase |
| Gene ID | 397638 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |