| HMRbase accession number | 21005 |
| Swiss-prot Accession number | P30552 (Sequence in FASTA format) |
| Description | Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR)(Cholecystokinin-2 receptor) (CCK2-R). |
| Source organism | Canis familiaris (Dog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Parietal cells, pancreas, brain and various neoplastic tissues. |
| Post translational modification | N/A |
| Function | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 453 Amino acids |
| Molecular weight | 48519 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1373504
2 Song I., Blandizzi C., Brown D.R., Kang D.H., Todisco A., Delvalle J.,del Tacca M., Owyang C., Yamada T.; "Molecular cloning and structural analysis of the canine gastrin/CCK-Breceptor gene."; Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
3 PubMed abstract 1373504
4 Song I., Blandizzi C., Brown D.R., Kang D.H., Todisco A., Delvalle J.,del Tacca M., Owyang C., Yamada T.; "Molecular cloning and structural analysis of the canine gastrin/CCK-Breceptor gene."; Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
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| Hormone | P01353 Detail in HMRbase
|
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors