A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21016 |
| Swiss-prot Accession number | P30937 (Sequence in FASTA format) |
| Description | Somatostatin receptor type 4 (SS4R). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Brain, lung, heart and islets. Moderate levels in the hippocampus, cortex and olfactory bulb. |
| Post translational modification | N/A |
| Function | Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. |
| Protein Length | 384 Amino acids |
| Molecular weight | 42088 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1360663 2 PubMed abstract 8175684 3 PubMed abstract 1360663 4 PubMed abstract 8175684 |
| Hormone | P60042 Detail in HMRbase |
| Gene ID | 25555 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |