A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21030 |
| Swiss-prot Accession number | P34974 (Sequence in FASTA format) |
| Description | Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R)(Melanocortin receptor 2) (MC2-R) (Adrenocorticotropin receptor). |
| Source organism | Bos taurus (Bovine) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Melanocytes and corticoadrenal tissue. |
| Post translational modification | N/A |
| Function | Receptor for ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. |
| Protein Length | 297 Amino acids |
| Molecular weight | 33293 |
| Domain Name | 7tm_1 |
| References | 1 Cone R.D., Mountjoy K.G.; "Molecular genetics of the ACTH and melanocyte-stimulating hormonereceptors."; Trends Endocrinol. Metab. 4:26-31(1993).
2 PubMed abstract 8305507 3 Cone R.D., Mountjoy K.G.; "Molecular genetics of the ACTH and melanocyte-stimulating hormonereceptors."; Trends Endocrinol. Metab. 4:26-31(1993). 4 PubMed abstract 8305507 |
| Hormone | P01190 Detail in HMRbase |
| Gene ID | 281299 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |