A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21031 |
| Swiss-prot Accession number | P34981 (Sequence in FASTA format) |
| Description | Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberinreceptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 398 Amino acids |
| Molecular weight | 45085 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8395824 2 PubMed abstract 8396925 3 PubMed abstract 8243797 4 PubMed abstract 7918619 5 PubMed abstract 8703031 6 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 15489334 8 PubMed abstract 9886052 9 PubMed abstract 8770906 10 PubMed abstract 8395824 11 PubMed abstract 8396925 12 PubMed abstract 8243797 13 PubMed abstract 7918619 14 PubMed abstract 8703031 15 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 16 PubMed abstract 15489334 17 PubMed abstract 9886052 18 PubMed abstract 8770906 |
| Hormone | P20396 Detail in HMRbase |
| Gene ID | 7201 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |