A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21034 |
| Swiss-prot Accession number | P34998 (Sequence in FASTA format) |
| Description | Corticotropin-releasing factor receptor 1 precursor (CRF-R) (CRF1)(Corticotropin-releasing hormone receptor 1) (CRH-R 1). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. |
| Post translational modification | C-terminal Ser or Thr residues may be phosphorylated. |
| Function | This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
| Protein Length | 444 Amino acids |
| Molecular weight | 50719 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 7692441 2 PubMed abstract 8243652 3 PubMed abstract 9757017 4 PubMed abstract 7811272 5 PubMed abstract 10598591 6 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 11425856 |
| Hormone | P06850 Detail in HMRbase |
| Gene ID | 1394 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |