A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21074 |
| Swiss-prot Accession number | Q16671 (Sequence in FASTA format) |
| Description | Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30)(Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIStype II receptor) (MISRII) (MRII). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; single-pass type I membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. |
| Protein Length | 573 Amino acids |
| Molecular weight | 62750 |
| Domain Name | Pkinase Pkinase_Tyr |
| References | 1 PubMed abstract 7493017 2 PubMed abstract 7488027 3 PubMed abstract 10589763 4 PubMed abstract 15489334 5 PubMed abstract 8872466 6 PubMed abstract 11549681 |
| Hormone | P03971 Detail in HMRbase |
| Gene ID | 269 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |