A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21110 |
| Swiss-prot Accession number | Q62893 (Sequence in FASTA format) |
| Description | Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30)(Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIStype II receptor) (MISRII) (MRII) (C14). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Membrane; single-pass type I membrane protein |
| Developmental Stage | Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14, 15, and 16 and in tubular and follicular structures of the fetal gonads. |
| Similarity | Belongs to the Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. |
| Protein Length | 557 Amino acids |
| Molecular weight | 59749 |
| Domain Name | Pkinase Pkinase_Tyr |
| References | 1 PubMed abstract 8536608 2 PubMed abstract 8119126 3 PubMed abstract 10570158 |
| Hormone | P49000 Detail in HMRbase |
| Gene ID | 29530 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |