A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21187 |
| Swiss-prot Accession number | Q9HBX9 (Sequence in FASTA format) |
| Description | Relaxin receptor 1 (Relaxin family peptide receptor 1) (Leucine-richrepeat-containing G-protein coupled receptor 7). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats. |
| Tissue Specificity | Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen. |
| Post translational modification | N/A |
| Function | Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. |
| Protein Length | 757 Amino acids |
| Molecular weight | 86993 |
| Domain Name | LRR_1 7tm_1 Ldl_recept_a |
| References | 1 PubMed abstract 10935549 2 PubMed abstract 11517286 3 PubMed abstract 12506116 |
| Hormone | P04090 Detail in HMRbase P04808 Detail in HMRbase Q8WXF3 Detail in HMRbase |
| Gene ID | 59350 |
| PDB ID | 2JM4 |
| Drugpedia | wiki |
| Comments |