A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21198 |
| Swiss-prot Accession number | Q9TU05 (Sequence in FASTA format) |
| Description | Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropinreceptor) (Melanocortin receptor 1) (MC1-R). |
| Source organism | Sus scrofa (Pig) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis. |
| Protein Length | 320 Amino acids |
| Molecular weight | 34592 |
| Domain Name | 7tm_1 |
| References | 1 Cho I.C., Jung J.K., Jung Y.H., Jeon J.T.; "The complete sequence of pig (Sus scrofa) MC1R gene."; Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 9799269 3 Cho I.C., Jung J.K., Jung Y.H., Jeon J.T.; "The complete sequence of pig (Sus scrofa) MC1R gene."; Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 9799269 |
| Hormone | P01192 Detail in HMRbase |
| Gene ID | 494018 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |