A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21241 |
| Swiss-prot Accession number | P49883 (Sequence in FASTA format) |
| Description | RecName: Ecdysone receptor;Alternative Name: Ecdysteroid receptor;Alternative Name: 20-hydroxy-ecdysone receptor;20E receptor;Alternative Name: EcRH;Alternative Name: Nuclear receptor subfamily 1 group H member 1; |
| Source organism | Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) |
| Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;Sphingidae; Sphinginae; Sphingini; Manduca. |
| Subcellular location | Nucleus |
| Developmental Stage | In the wing disks levels increase on day 2 fifth larval instar reaching a maximum on day 5, and then decrease sharply on day 6. In the prothoracic glands levels increase sharply on day 2 then remain high throughout the larval-pupal transformation and after pupal ecdysis. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | It is found in both larval wing disks and pupal wings and in prothoracic glands. |
| Post translational modification | N/A |
| Function | Receptor for ecdysone. Binds to ecdysone response elements (ECRES). |
| Protein Length | 556 Amino acids |
| Molecular weight | 62830 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7633469 |
| Hormone | Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |