A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21313 |
| Swiss-prot Accession number | P41235 (Sequence in FASTA format) |
| Description | RecName: Hepatocyte nuclear factor 4-alpha;HNF-4-alpha;Alternative Name: Transcription factor HNF-4;Alternative Name: Nuclear receptor subfamily 2 group A member 1;Alternative Name: Transcription factor 14; |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. |
| Function | Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine. |
| Protein Length | 474 Amino acids |
| Molecular weight | 52785 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 8964514 2 PubMed abstract 8622695 3 PubMed abstract 8945471 4 PubMed abstract 11780052 5 PubMed abstract 7926813 6 PubMed abstract 7568236 7 PubMed abstract 14982928 8 PubMed abstract 9313765 9 PubMed abstract 9243109 10 PubMed abstract 9267996 11 PubMed abstract 9449683 |
| Hormone | N/A |
| Gene ID | 3172 |
| PDB ID | 1PZL |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |