A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21316 |
| Swiss-prot Accession number | Q91766 (Sequence in FASTA format) |
| Description | RecName: Hepatocyte nuclear factor 4-alpha;HNF-4-alpha;Alternative Name: Nuclear receptor subfamily 2 group A member 1; |
| Source organism | Xenopus laevis (African clawed frog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;Xenopodinae; Xenopus; Xenopus. |
| Subcellular location | Nucleus |
| Developmental Stage | Maternal protein which is distributed within an animal-to-vegetal gradient in the embryo. Present throughout the entire development. |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Expressed in liver and kidney. |
| Post translational modification | N/A |
| Function | Transcription factor; binds and activates the promoter for the HNF1-alpha gene. Potential initiator of a transcriptional cascade within a subset of cells committed to a specific developmental program. Could be a determinant for asymmetry in early development. |
| Protein Length | 464 Amino acids |
| Molecular weight | 51967 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 8808405 |
| Hormone | N/A |
| Gene ID | 379762 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |