A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21341 |
| Swiss-prot Accession number | Q61066 (Sequence in FASTA format) |
| Description | RecName: Nuclear receptor subfamily 0 group B member 1;Alternative Name: Nuclear receptor DAX-1; |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus (By similarity). Cytoplasm (By similarity). Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus (By similarity) |
| Developmental Stage | Expressed in E5.5 throughout the embryo except in the proximal visceral endoderm. |
| Similarity | Belongs to the nuclear hormone receptor family. NR0 subfamily. |
| Tissue Specificity | Expressed in adult cerebral cortex, spinal cord, thymus, heart, lung, ovary, testis, adrenal gland, hypothalamus, spleen and kidney. |
| Post translational modification | N/A |
| Function | Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). |
| Protein Length | 472 Amino acids |
| Molecular weight | 52576 |
| Domain Name | Hormone_recep |
| References | 1 PubMed abstract 8921887 2 PubMed abstract 8756567 3 PubMed abstract 16466956 |
| Hormone | N/A |
| Gene ID | 11614 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |