A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21366 |
| Swiss-prot Accession number | O75469 (Sequence in FASTA format) |
| Description | RecName: Nuclear receptor subfamily 1 group I member 2;Alternative Name: Orphan nuclear receptor PXR;Alternative Name: Pregnane X receptor;Alternative Name: Orphan nuclear receptor PAR1;Alternative Name: Steroid and xenobiotic receptor;SXR |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Expressed in liver, colon and small intestine. |
| Post translational modification | N/A |
| Function | Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A4 and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics. |
| Protein Length | 434 Amino acids |
| Molecular weight | 49762 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 9784494 2 PubMed abstract 9727070 3 PubMed abstract 9770465 4 PubMed abstract 11668216 5 PubMed abstract 15489334 6 PubMed abstract 11297522 7 PubMed abstract 12606758 8 PubMed abstract 11408620 9 PubMed abstract 15618712 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 8856 |
| PDB ID | 1ILG 1ILH 1M13 1NRL 1SKX 2O9I |
| Drugpedia | wiki |
| Comments |