A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21371 |
| Swiss-prot Accession number | Q14994 (Sequence in FASTA format) |
| Description | RecName: Nuclear receptor subfamily 1 group I member 3;Alternative Name: Constitutive androstane receptor;CAR;Alternative Name: Constitutive activator of retinoid response;Constitutive active response;Alternative Name: Orphan nuclear receptor MB67 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Predominantly expressed in liver. |
| Post translational modification | N/A |
| Function | Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. |
| Protein Length | 352 Amino acids |
| Molecular weight | 39942 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 8114692 2 PubMed abstract 15489334 3 PubMed abstract 8603043 4 PubMed abstract 15610735 5 PubMed abstract 15618763 |
| Hormone | N/A |
| Gene ID | 9970 |
| PDB ID | 1XV9 1XVP |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |