A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21398 |
| Swiss-prot Accession number | P22829 (Sequence in FASTA format) |
| Description | Nuclear receptor subfamily 4 group A member 1;Alternative Name: Orphan nuclear receptor HMR;Alternative Name: Nerve growth factor-induced protein I-B;NGFI-B;Alternative Name: NUR77 |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Expressed in lung, brain and superior cervical ganglia. High levels are seen in the adrenal tissue. |
| Post translational modification | Phosphorylation of Ser-350 results in decrease in NBRE binding while phosphorylation of Ser-340 has little effect on it. |
| Function | Probable nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3'. |
| Protein Length | 597 Amino acids |
| Molecular weight | 64282 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 3272167 2 PubMed abstract 15489334 3 PubMed abstract 8395013 4 PubMed abstract 1314418 5 PubMed abstract 8227042 6 PubMed abstract 10331876 |
| Hormone | N/A |
| Gene ID | 79240 |
| PDB ID | 1CIT 1YJE |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |