A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21401 |
| Swiss-prot Accession number | P43354 (Sequence in FASTA format) |
| Description | Nuclear receptor subfamily 4 group A member 2;Alternative Name: Orphan nuclear receptor NURR1;Alternative Name: Immediate-early response protein NOT;Alternative Name: Transcriptionally-inducible nuclear receptor |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus (Probable) |
| Developmental Stage | Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle. |
| Similarity | Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. |
| Post translational modification | N/A |
| Function | Probable nuclear receptor. May function as a general coactivator of gene transcription. Detection of the protein in the brain, indicates that it is not mandatorily associated with cell cycle progression. |
| Protein Length | 598 Amino acids |
| Molecular weight | 66591 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7877627 2 PubMed abstract 10216262 3 PubMed abstract 10216261 4 PubMed abstract 15489334 5 PubMed abstract 7706727 6 PubMed abstract 17081983 |
| Hormone | N/A |
| Gene ID | 4929 |
| PDB ID | 1OVL |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |