A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21408 |
| Swiss-prot Accession number | O00482 (Sequence in FASTA format) |
| Description | Nuclear receptor subfamily 5 group A member 2;Alternative Name: Alpha-1-fetoprotein transcription factor;Alternative Name: Hepatocytic transcription factor;Alternative Name: B1-binding factor;hB1F;Alternative Name: CYP7A promoter-binding factor;Alternative Name: Liver receptor homolog 1;LRH-1 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus (Probable) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in hepG2. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and hepG2 cells. |
| Post translational modification | N/A |
| Function | Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsable for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. |
| Protein Length | 541 Amino acids |
| Molecular weight | 61331 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 9786908 2 PubMed abstract 10359768 3 PubMed abstract 11595170 4 PubMed abstract 9858833 5 PubMed abstract 15707893 6 PubMed abstract 16289203 7 PubMed abstract 15723037 8 PubMed abstract 15897460 |
| Hormone | N/A |
| Gene ID | 2494 |
| PDB ID | 1YOK 1YUC 1ZDU 2A66 |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |