A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21423 |
| Swiss-prot Accession number | Q0ZAQ8 (Sequence in FASTA format) |
| Description | Peroxisome proliferator-activated receptor delta;PPAR-delta;Alternative Name: PPAR-beta;Alternative Name: Nuclear receptor subfamily 1 group C member 2 |
| Source organism | Canis familiaris (Dog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Decreases expression of NPC1L1 once activated by a ligand (By similarity). |
| Protein Length | 441 Amino acids |
| Molecular weight | 49776 |
| Domain Name | Hormone_recep zf-C4 |
| References | ---- |
| Hormone | Detail in HMRbase |
| Gene ID | 481756 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |