A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21430 |
| Swiss-prot Accession number | P37238 (Sequence in FASTA format) |
| Description | Peroxisome proliferator-activated receptor gamma;PPAR-gamma;Alternative Name: Nuclear receptor subfamily 1 group C member 3 |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus |
| Developmental Stage | It appears first at 13.5 dpc and increases until birth. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Highest expression in adipose tissue. Also found in liver, skeletal muscle, heart, adrenal gland, spleen, kidney and intestine. Isoform 2 is more abundant than isoform 1 in adipose tissue. |
| Post translational modification | N/A |
| Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. |
| Protein Length | 505 Amino acids |
| Molecular weight | 57598 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7926726 2 PubMed abstract 8240342 3 PubMed abstract 8262913 4 PubMed abstract 8041794 5 PubMed abstract 8647948 6 PubMed abstract 7838715 7 PubMed abstract 9325263 8 PubMed abstract 10788465 9 PubMed abstract 15687259 10 PubMed abstract 17595322 |
| Hormone | Detail in HMRbase |
| Gene ID | 19016 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |