A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21433 |
| Swiss-prot Accession number | O88275 (Sequence in FASTA format) |
| Description | Peroxisome proliferator-activated receptor gamma;PPAR-gamma;Alternative Name: Nuclear receptor subfamily 1 group C member 3 |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Highest expression in adipose tissue. |
| Post translational modification | Phosphorylated by MAPK. The phosphorylation inhibits PPAR gamma activity. |
| Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. |
| Protein Length | 505 Amino acids |
| Molecular weight | 57567 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 10438514 2 PubMed abstract 10797535 3 PubMed abstract 8953045 4 PubMed abstract 9030579 5 PubMed abstract 8943212 |
| Hormone | Detail in HMRbase |
| Gene ID | 25664 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |