A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21449 |
| Swiss-prot Accession number | P10276 (Sequence in FASTA format) |
| Description | Retinoic acid receptor alpha;RAR-alpha;Alternative Name: Nuclear receptor subfamily 1 group B member 1 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Phosphorylated. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity (By similarity). |
| Function | This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression. |
| Protein Length | 462 Amino acids |
| Molecular weight | 50771 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2825036 2 PubMed abstract 8302850 3 PubMed abstract 10337631 4 PubMed abstract 15489334 5 PubMed abstract 2175878 6 PubMed abstract 2825025 7 PubMed abstract 8562957 8 PubMed abstract 12691149 9 PubMed abstract 9267036 10 PubMed abstract 10567404 11 PubMed abstract 11971969 |
| Hormone | N/A |
| Gene ID | 5914 |
| PDB ID | 1DKF 1DSZ |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |