A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21467 |
| Swiss-prot Accession number | Q8R1B8 (Sequence in FASTA format) |
| Description | Nuclear receptor ROR-beta;Alternative Name: Retinoid-related orphan receptor-beta;Alternative Name: Nuclear receptor RZR-beta;Alternative Name: Nuclear receptor subfamily 1 group F member 2 |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus (Probable) |
| Developmental Stage | Highest level in retina of stage E17.5 embryos. Lower level in postnatal and adult retina. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Expressed in inner and outer neuroblastic layer as well as in the ganglion cell layer of the developing retina. |
| Post translational modification | N/A |
| Function | Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter. |
| Protein Length | 470 Amino acids |
| Molecular weight | 53118 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 16574740 2 PubMed abstract 15489334 3 PubMed abstract 9670004 |
| Hormone | N/A |
| Gene ID | 225998 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |