A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21468 |
| Swiss-prot Accession number | P45446 (Sequence in FASTA format) |
| Description | Nuclear receptor ROR-beta;Alternative Name: Retinoid-related orphan receptor-beta;Alternative Name: Nuclear receptor RZR-beta;Alternative Name: Nuclear receptor subfamily 1 group F member 2 |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Nucleus (Probable) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Isoform 2 expressed with circadian rhythm in eye and pineal gland with highest levels shortly after midnight. Isoform 1 expressed in cortex, thalamus, and hypothalamus. |
| Post translational modification | N/A |
| Function | Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter. |
| Protein Length | 470 Amino acids |
| Molecular weight | 53201 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7935491 2 PubMed abstract 9729429 3 PubMed abstract 11689423 4 PubMed abstract 12958591 |
| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | 1K4W 1N4H 1NQ7 |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |