A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21470 |
| Swiss-prot Accession number | P51450 (Sequence in FASTA format) |
| Description | Nuclear receptor ROR-gamma;Alternative Name: Retinoid-related orphan receptor-gamma;Alternative Name: Nuclear receptor RZR-gamma;Alternative Name: Nuclear receptor subfamily 1 group F member 3;Alternative Name: Thymus orphan receptor;TOR |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus (Probable) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Isoform 1 is widely expressed with highest levels in muscle, kidney and liver. Isoform 2 is expressed primarily in immature thymocytes. Neither isoform is expressed in spleen or bone marrow. |
| Post translational modification | N/A |
| Function | Orphan nuclear receptor. Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus. |
| Protein Length | 516 Amino acids |
| Molecular weight | 58117 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 8973331 2 PubMed abstract 9403063 3 PubMed abstract 8614404 4 PubMed abstract 9881970 5 PubMed abstract 10602018 6 PubMed abstract 15489334 |
| Hormone | N/A |
| Gene ID | 19885 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |