A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21642 |
| Swiss-prot Accession number | P34995 (Sequence in FASTA format) |
| Description | Prostaglandin E2 receptor EP1 subtype;Alternative Name: Prostanoid EP1 receptor;Alternative Name: PGE receptor, EP1 subtype |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart. |
| Post translational modification | Phosphorylated (Potential). |
| Function | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. |
| Protein Length | 402 Amino acids |
| Molecular weight | 41801 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8253813 2 PubMed abstract 15489334 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 5731 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |