A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21647 |
| Swiss-prot Accession number | P21731 (Sequence in FASTA format) |
| Description | Thromboxane A2 receptor;TXA2-R;Alternative Name: Prostanoid TP receptor |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. |
| Protein Length | 369 Amino acids |
| Molecular weight | 40092 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1825698 2 PubMed abstract 8034687 3 PubMed abstract 7896853 4 PubMed abstract 7965765 5 PubMed abstract 8227091 6 PubMed abstract 15057824 7 PubMed abstract 15489334 8 PubMed abstract 8246916 9 PubMed abstract 7929844 |
| Hormone | Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | 1LBN |
| Drugpedia | wiki |
| Comments |