A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21683 |
| Swiss-prot Accession number | P03373 (Sequence in FASTA format) |
| Description | Gag polyprotein;Contains: Core protein p19;Contains: Core protein p2A;Contains: Core protein p2B;Contains: Core protein p10;Contains: V-erbA oncogene; Fragment |
| Source organism | Avian erythroblastosis virus (strain ES4) |
| Taxonomical Classification | Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;Alpharetrovirus. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Acts as a thyroid-hormone receptor antagonist. The v- ErbA oncogene cooperates with v-ErbB and other primarily sarcoma- inducing oncogenes in transformation of erythroblasts. It is non transforming by itself and cannot induce self-renewal of erythroblasts. Instead it blocks the residual capacity of the v- ErbB cells to differentiate terminally. |
| Protein Length | 555 Amino acids |
| Molecular weight | 61661 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2884103 2 PubMed abstract 6328658 3 PubMed abstract 2733791 |
| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |