A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20327 |
| Swiss-prot Accession number | P28223 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 2A receptor (5-HT-2A) (Serotonin receptor 2A) (5-HT-2). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein (By similarity). Note=Localizes to the post-synaptic thickening of axo-dendritic synapses (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. |
| Protein Length | 471 Amino acids |
| Molecular weight | 52603 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1722404 2 PubMed abstract 1323014 3 PubMed abstract 8035173 4 Puhl H.L. III, Ikeda S.R., Aronstam R.S.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15057823 6 PubMed abstract 15489334 7 Tritch R.J., Robinson D.L., Sahagan B.G., Horlick R.A.; "Cloning and nucleotide sequence of the human(5HT) type 2 receptor."; Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases. 8 PubMed abstract 1330647 9 PubMed abstract 11150294 10 PubMed abstract 14988405 11 PubMed abstract 8655141 12 PubMed abstract 10581480 13 PubMed abstract 10391209 14 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 15 PubMed abstract 1722404 16 PubMed abstract 1323014 17 PubMed abstract 8035173 18 Puhl H.L. III, Ikeda S.R., Aronstam R.S.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. 19 PubMed abstract 15057823 20 PubMed abstract 15489334 21 Tritch R.J., Robinson D.L., Sahagan B.G., Horlick R.A.; "Cloning and nucleotide sequence of the human(5HT) type 2 receptor."; Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases. 22 PubMed abstract 1330647 23 PubMed abstract 11150294 24 PubMed abstract 14988405 25 PubMed abstract 8655141 26 PubMed abstract 10581480 27 PubMed abstract 10391209 28 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). |
| Hormone | Detail in HMRbase |
| Gene ID | 3356 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |