A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21359 |
| Swiss-prot Accession number | Q13133 (Sequence in FASTA format) |
| Description | RecName: Oxysterols receptor LXR-alpha;Alternative Name: Liver X receptor alpha;Alternative Name: Nuclear orphan receptor LXR-alpha;Alternative Name: Nuclear receptor subfamily 1 group H member 3; |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus (Potential) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals. |
| Post translational modification | N/A |
| Function | Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis. |
| Protein Length | 447 Amino acids |
| Molecular weight | 50396 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7744246 2 PubMed abstract 15489334 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 10062 |
| PDB ID | 1UHL |
| Drugpedia | wiki |
| Comments |