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Receptor

Search Result - 1

HMRbase accession number	20011
Swiss-prot Accession number	P05710 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R) (Lactogen receptor).
Source organism	Rattus norvegicus (Rat)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular location	Membrane; Single-pass type I membrane protein
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin.
Protein Length	610 Amino acids
Molecular weight	68599
Domain Name	fn3
References	1  PubMed abstract 2293022 2  PubMed abstract 2159291 3   Banville D., Stocco R., Murthy K.K., Boie Y., Kelly P.A.; Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases. 4  PubMed abstract 2832068 5  PubMed abstract 1718958 6  PubMed abstract 7929319
Hormone	P01237   Detail in HMRbase    P09321   Detail in HMRbase    P21702   Detail in HMRbase
Gene ID	24684
PDB ID	1F6F
Drugpedia	wiki
Comments

Search Result - 2

HMRbase accession number	20014
Swiss-prot Accession number	Q04594 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R) (CPRLP).
Source organism	Gallus gallus (Chicken)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Subcellular location	Membrane; Single-pass type I membrane protein
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 4 fibronectin type-III domains.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin.
Protein Length	831 Amino acids
Molecular weight	94102
Domain Name	fn3
References	1  PubMed abstract 1445292
Hormone	P14676   Detail in HMRbase
Gene ID	395660
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 3

HMRbase accession number	20875
Swiss-prot Accession number	Q90374 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R).
Source organism	Columba livia (Domestic pigeon)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;Neognathae; Columbiformes; Columbidae; Columba.
Subcellular location	Membrane; Single-pass type I membrane protein
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 4 fibronectin type-III domains.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin.
Protein Length	830 Amino acids
Molecular weight	94507
Domain Name	fn3
References	1  PubMed abstract 7516866
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 4

HMRbase accession number	20876
Swiss-prot Accession number	Q91513 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R).
Source organism	Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Labroidei;Cichlidae; African cichlids; Pseudocrenilabrinae; Tilapiini;Oreochromis.
Subcellular location	Membrane; Single-pass type I membrane protein
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin.
Protein Length	630 Amino acids
Molecular weight	70811
Domain Name	fn3
References	1  PubMed abstract 7597076
Hormone	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Hormone for this Receptor are either unknown or have not yet been curated

Search Result - 5

HMRbase accession number	20975
Swiss-prot Accession number	O46561 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R) (OPR).
Source organism	Ovis aries (Sheep)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis.
Subcellular location	Membrane; Single-pass type I membrane protein
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains.
Tissue Specificity	Expressed in all tissues examined; liver, pituitary, adrenal gland, ovary and fetal liver.
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin.
Protein Length	581 Amino acids
Molecular weight	65235
Domain Name	fn3
References	1  PubMed abstract 9343303 2  PubMed abstract 9832462 3   Anthony R.V., Smith G.W., Duong A., Pratt S.L., Smith M.F.; "Two forms of the prolactin receptor messenger ribonucleic acid arepresent in ovine fetal liver and adult ovary."; Endocrine 3:291-295(1995).
Hormone	P01240   Detail in HMRbase
Gene ID	443020
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 6

HMRbase accession number	20982
Swiss-prot Accession number	P14787 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R).
Source organism	Oryctolagus cuniculus (Rabbit)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;Oryctolagus.
Subcellular location	Membrane; Single-pass type I membrane protein
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin.
Protein Length	616 Amino acids
Molecular weight	68840
Domain Name	fn3
References	1  PubMed abstract 2928321 2  PubMed abstract 2289615 3  PubMed abstract 9094747
Hormone	Q28632   Detail in HMRbase
Gene ID	100009046
PDB ID	1AN3
Drugpedia	wiki
Comments

Search Result - 7

HMRbase accession number	20986
Swiss-prot Accession number	P16471 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Membrane; Single-pass type I membrane protein. Secreted. Note=Isoform 7
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains.
Tissue Specificity	Expressed in breast, placenta, kidney, liver and pancreas.
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin. Isoforms 4 and 6 are unable to transduce prolactin signaling.
Protein Length	622 Amino acids
Molecular weight	69506
Domain Name	fn3
References	1  PubMed abstract 2558309 2  PubMed abstract 10585417 3  PubMed abstract 10084611 4  PubMed abstract 11518703 5  PubMed abstract 12351696 6  PubMed abstract 12580759 7  PubMed abstract 15489334 8  PubMed abstract 7768908 9  PubMed abstract 16740656 10  PubMed abstract 7984244
Hormone	P01236   Detail in HMRbase
Gene ID	5618
PDB ID	1BP3   3D48
Drugpedia	wiki
Comments

Search Result - 8

HMRbase accession number	21068
Swiss-prot Accession number	Q02092 (Sequence in FASTA format)
Description	Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains: Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)].
Source organism	Gallus gallus (Chicken)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Subcellular location	Cell membrane; single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain.
Tissue Specificity	Broad specificity.
Post translational modification	On GH binding, proteolytically cleaved, in vitro, to produce GHBP. On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2 (By similarity). On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity). Proteolytically cleaved, in vitro, to release the growth hormone-binding protein (GHBP).
Function	Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling (By similarity).
Protein Length	608 Amino acids
Molecular weight	68573
Domain Name	fn3
References	1  PubMed abstract 2036984 2  PubMed abstract 8114754 3  PubMed abstract 10082631 4  PubMed abstract 11997231
Hormone	P08998   Detail in HMRbase
Gene ID	408184
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 9

HMRbase accession number	21079
Swiss-prot Accession number	Q28172 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R).
Source organism	Bos taurus (Bovine)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular location	Membrane; Single-pass type I membrane protein
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains.
Tissue Specificity	Expressed in all tissues examined; liver, peripheral blood lymphocytes, endometrium, corpus luteum, intestine, fetal thymus, fetal spleen, fetal liver and fetal brain.
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin.
Protein Length	581 Amino acids
Molecular weight	65153
Domain Name	fn3
References	1  PubMed abstract 1338725 2  PubMed abstract 9231767 3  PubMed abstract 7738463 4  PubMed abstract 9343303
Hormone	P01239   Detail in HMRbase
Gene ID	281422
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 10

HMRbase accession number	21080
Swiss-prot Accession number	Q28235 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R).
Source organism	Cervus elaphus (Red deer)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Cervidae; Cervinae; Cervus.
Subcellular location	Membrane; Single-pass type I membrane protein
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin.
Protein Length	581 Amino acids
Molecular weight	65159
Domain Name	fn3
References	1  PubMed abstract 7561644
Hormone	Q6UC74   Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 11

HMRbase accession number	21116
Swiss-prot Accession number	Q6JTA8 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R).
Source organism	Sus scrofa (Pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular location	Membrane; Single-pass type I membrane protein (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin (By similarity).
Protein Length	625 Amino acids
Molecular weight	69573
Domain Name	fn3
References	1   Trott J.F., Hovey R.C.; "Cloning and characterization of multiple forms of the pig (Susscrofa) prolactin receptor."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 2  PubMed abstract 9321486
Hormone	P01238   Detail in HMRbase
Gene ID	414916
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 12

HMRbase accession number	21164
Swiss-prot Accession number	Q91094 (Sequence in FASTA format)
Description	Prolactin receptor precursor (PRL-R) (TPRLR).
Source organism	Meleagris gallopavo (Common turkey)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;Neognathae; Galliformes; Phasianidae; Meleagris.
Subcellular location	Membrane; Single-pass type I membrane protein
Developmental Stage	N/A
Similarity	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 4 fibronectin type-III domains.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This is a receptor for the anterior pituitary hormone prolactin.
Protein Length	831 Amino acids
Molecular weight	94395
Domain Name	fn3
References	1  PubMed abstract 8902221 2   Pitts G.R., You S.K., Foster D.N., el Halawani M.E.; Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases.
Hormone	P17572   Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 13

HMRbase accession number	22983
Swiss-prot Accession number	B3Y063 (Sequence in FASTA format)
Description	Leptin receptor
Source organism	Fugu rubripes (Japanese pufferfish) (Takifugu rubripes)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes;Tetradontoidea; Tetraodontidae; Takifugu.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	N/A
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	1116 Amino acids
Molecular weight	124570
Domain Name	fn3
References	1  PubMed abstract 18582469
Hormone	Q588G0   Detail in HMRbase
Gene ID	100174783
PDB ID	N/A
Drugpedia	wiki
Comments