The prediction is based on the distinct binding motifs in binders distinguishable from nonbinders. The MOT used in this server is simple to implement and effective. It has discriminated 97 -99% sequences correctly in HLA-DR1, HLA-DR2 and HLA-DR5 allele. Breifly the algorithm in MOT is to optimize each element of matrix to have highest discriminating accuracy.
Just copy and paste you amino acid sequence in sequence window
Note: Only single letter code of amino acids is recognized. No sequence format is required.