NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

FAQs


  1. 1. What is NPACT?
  2. 2. Can I search NPACT for a molecule of a interest?
  3. 3. Can I search NPACT by biological activities such as IC50, EC50, ED50, GI50?
  4. 4. Can I download the structure of molecule of my interest?
  5. 5. Can I search molecule having activity against particular cancer?
  6. 6. Can we get In-vivo anticancer activity of compounds?
  7. 7. Can I search compounds that are provided by a particular company?
  8. 8. Can we search compounds based on SMILES?
  9. 9. Can we search compounds based on InChiKey?
  10. 10. Can I enter details of a new compound not available in NPACT?
  11. 11. What can I do if I have found in error in NPACT?
  12. 12. Can I search compounds reported to have activity against a cell line?
  13. 13. Can I find molecule inhibiting a target?

1. NPACT is a curated database of Plant derived natural compounds that exhibit anti-cancerous activity. It contains 1574 entries and each record provides information on their structure, properties (physical, elemental and topological), cancer type, cell lines, inhibitory values (IC50, ED50, EC50, GI50), molecular targets, commercial suppliers and drug likeness of compounds. NPACT concentrates on anti-cancer natural compounds found in plants only. NPACT is unique in providing bioactivities of these natural compounds against different cancer cell lines and their molecular target. It includes data extracted PubMed by reading 762 full text articles. It currently provides details for 1574 bio-active compounds having activity against 353 cancer cell lines which corresponds to about 5214 compound-cell line interactions. NPACT also provides information on protein targets that have been demonstrated in cancer cell lines to be inhibited by these naturally occuring compounds. At present the database contents around 1980 experimentally validated compound-target interactions. Each record in the NPACT is also hyperlinked to various other similar databases like Super Natural Database, Herbal Ingredients' Targets Database (HIT), Comparative Toxicogenomics Database (CTD) and PubChem. Top

2. There are several ways to find the desired compound. If you already know the compound name, you can simply use the Search by Compound name option. Otherwise desired compound can be searched by SMILES, InchIKey, SMARTS, CAS No.
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3. Use the options IC50, ED50, EC50, GI50 at the Advance Search facility of NPACT.
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4. Yes, you can download the 3D mol File of the desired compound from the link shown below on the page showing Compound details.

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5. Yes, you can search your molecule of interest for a particular cancer. Go to browse page, and select type of cancer.
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6. On compound display page, click on in-vivo anticancer activity.
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7. Use Browse facility of NPACT. From the option "Suppliers" you can retrieve the relevant data.
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8. Use the SMILE option in the Search facility of NPACT.
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9. Use the InchIKey option in the Search facility of NPACT.
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10. Yes you can definitely enter the details. Use Data Submission form of NPACT or else can also Contact Us.
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11. In case you find any error in NPACT you can Email us at smagarwal@yahoo.com (Contact Us).
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12. A user can first search if the activity against cell line of his interest is listed in Statistics Page, which contains the list of 353 cell lines for which data has been incorporated at present in NPACT. Then the user can use Browse by Cell line option in order to identify the compounds that have been reported to demonstrate the activity.
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13. Yes, you can find your molecule inhibiting particular target by using Browse facility of NPACT. From the option "Target" you can retrieve the relevant data..
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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.