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Compound: Lupinifolin

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Target

Inhibitory Conc

Remark

Reference

Two-stage carcinogenesis test focusing on mouse skin papillomas induced by DMBA as an initiator and TPA as a promoter.

When lupinifolin was applied before TPA treatment, it delayed the formation of papillomas. In the group treated with lupinifolin, only about 20 and 60% of mice bore papillomas after 10 and 15 weeks of promotion unlike the positive control where 100% mice bore papillomas after 10 weeks, respectively, and only 93% of the mice bore papillomas, even after 20 weeks. Also lupinifolin reduced the number of papillomas/mouse. Less than 2.1 and 3.2 papillomas were formed/mouse after 12 and 17 weeks of promotion, respectively, and only about 4.3 papillomas were formed/mouse even after 20 weeks.

11790450

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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