NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

a

Compound: 6-shogaol

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

TIMP1

TIMP metallopeptidase inhibitor 1

7076

Hepatoma

Hep-3B

-

-

-

-

The physiological activity of MMP-9 is significantly related to the activity of uPA and TIMPs. The protein level of TIMP-1 in HepG2 and Hep3B cells was increased in a dose-dependent manner along with a gradual increase in the concentrations of 6-shogaol used for 24 h treatment. Regulation of TIMP-1 by 6-shogaol in Hep3B cells may on the transcriptional leve.

20521273

TIMP1

TIMP metallopeptidase inhibitor 1

7076

Hepatoma

Hep G2

-

-

-

-

The physiological activity of MMP-9 is significantly related to the activity of uPA and TIMPs. The protein level of TIMP-1 in HepG2 and Hep3B cells was increased in a dose-dependent manner along with a gradual increase in the concentrations of 6-shogaol used for 24 h treatment. Regulation of TIMP-1 by 6-shogaol in Hep3B cells may on the transcriptional leve.

20521273

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.