NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Apigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CYPIA1cytochrome P450, family 1, subfamily A, polypeptide 11543Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.70.02 µM---Apigenin potently inhibited Cyp1A activity with an IC50 of 0.02 µM Cyp1A, which is e.g. involved in the activation of carcinogens from grilled meat, as a model phase 1 enzyme, and measured the potential of beer constituents to inhibit its enzymatic activity.Phytochemistry Reviews 1: 369-377, 2002

 






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