NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Beta-Ionone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Human osteosarcomaU2os----Our immunocytochemistry findings for Bax and Bcl2 revealed that b-ionone increased the expression of Bax but decreased the expression of Bcl2. The Bax protein was relatively concentrated in the mitochondria in U2os cells after 200 lM b-ionone treatment for 48 .19757179
BCL2B-cell CLL/lymphoma 2596Human osteosarcomaU2os----Our immunocytochemistry findings for Bax and Bcl2 revealed that b-ionone increased the expression of Bax but decreased the expression of Bcl.19757179
CASP3caspase 3, apoptosis-related cysteine peptidase836Human osteosarcomaU2os----The Caspase-3 cellular activity showed a significant increase in cells treated with 200 lM b-ionone for 48 h compared with cells treated with b-ionone for 12 or 24 h. Because the activity of Caspase-3 was significantly increased in U2os cells treated with 200 lM b-ionone for 48 h, this treatment was considered to represent the optimal induction condition of apoptosis.19757179
CCND1cyclin D1595Breast adenocarcinomaMCF-7----A significant, concentration-dependent decrease in expression of the early G1 phase cyclin D1 was observed in MCF-7 cells treated with beta-ionone.15450939
CCNE1cyclin E1898Breast adenocarcinomaMCF-7----Protein levels of cyclin E in cells treated with 400 or 500 mM b-ionone.15450939
CDK2cyclin-dependent kinase 21017Breast adenocarcinomaMCF-7----Protein levels of CDK 2, decreased significantly in cells treated with 400 or 500 mM b-ionone.15450939
CycACyclin A39340Breast adenocarcinomaMCF-7----Expression of cyclin A, the S phase CDK 2 activator, decreased significantly following treatment of cells with beta-ionone.15450939
CYCScytochrome c54205Human osteosarcomaU2os----Cytochrome c is released from the mitochondria in response to b-ionone via Bcl2 family-regulated mechanisms.The release of cytochrome c is a characteristic of cellular apoptosis. In U2os cells treated with b-ionone for 48 h, the cytochrome c protein was relatively diffusely expressed in the cytosol.19757179
TP53tumor protein p537157Human osteosarcomaU2os----The immunocytochemical results of p53 showed that the expression of p53 was increased by b-ionone in dosedependent manner over 48 h. Besides, p53 protein was detected in U2os cells that incubated with 200 lM b-ionone for 12, 24,36, and 48 h, the expression of p53 was increased by b-ionone in time-dependent manner.19757179

 






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