NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Beta-lapachone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MAPK8mitogen-activated protein kinase 85599LeukemiaU-937----The activation of AP-1 by TNF is regulated in part by JNK. JNK activation was increased 16-fold in response to TNF. However, it gradually decreased with increasing concentration of beta-lapachone and was reduced to the basal levels by 5 mM beta-lapachone. beta-lapachone by itself did not activate JNK.10075082

 






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