NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Brucine N-oxide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Hepatocellular carcinomaSMMC-7721----major alkaloids present in the seed of Strychnos nux-vomica are effective against SMMC-7721 cells proliferation, among which brucine proceeds SMMC-7721 cells death via apoptosis, probably through the participation of caspase 3.17449162
COX-2cytochrome c oxidase subunit II4513Hepatocellular carcinomaSMMC-7721----major alkaloids present in the seed of Strychnos nux-vomica are effective against SMMC-7721 cells proliferation, among which brucine proceeds SMMC-7721 cells death via apoptosis, probably through the participation of cyclooxygenase 2.17449162
PTGER3prostaglandin E receptor 3 (subtype EP3)5733Hepatocellular carcinomaSMMC-7721----brucine dose-dependently decreased the protein abundance of COX-2.Meanwhile, brucine also dose-dependently suppressed the release of PGE2 content in the supernatant of SMMC cell.17449162

 






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