NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

a

Compound: Butein

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

BAX

BCL2-associated X protein

581

Prostate Cancer

LNCaP

-

-

-

-

The deregulation of apoptosis is studied by the expression of Bax and Bcl2. Bax is proapoptotic protein, there was a significant increase in the protein expression of Bax with a dose-dependent on treatment of LNCaP and CWR22Rm1 cells with butein.

22114764

BAX

BCL2-associated X protein

581

Prostrate Carcinoma

CWR22Rm1

-

-

-

-

The deregulation of apoptosis is studied by the expression of Bax and Bcl2. Bax is proapoptotic protein, there was a significant increase in the protein expression of Bax with a dose-dependent on treatment of LNCaP and CWR22Rm1 cells with butein.

22114764

BAX

BCL2-associated X protein

581

Human promyelocytic leukemia

HL-60

-

-

-

-

The treatment of HL-60 cells with butein increased the expression of Bax protein

11393587

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.