NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

a

Compound: Butein

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

BCL2

B-cell CLL/lymphoma 2

596

Prostate Cancer

LNCaP

-

-

-

-

The deregulation of apoptosis is studied by the expression of Bax and Bcl2. Bcl2 is anti-apoptotic, there was a significant decrease in the protein expression of Bcl2 on treatment of LNCaP and CWR22Rm1 cells with butein.

22114764

BCL2

B-cell CLL/lymphoma 2

596

Prostrate Carcinoma

CWR22Rm1

-

-

-

-

The deregulation of apoptosis is studied by the expression of Bax and Bcl2. Bcl2 is anti-apoptotic, there was a significant decrease in the protein expression of Bcl2 on treatment of LNCaP and CWR22Rm1 cells with butein.

22114764

BCL2

B-cell CLL/lymphoma 2

596

Human promyelocytic leukemia

HL-60

-

-

-

-

The treatment of HL-60 cells with butein decreased the expression of Bcl-2 protein

11393587

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.