NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Butein

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CCND1cyclin D1595Prostate CancerLNCaP----LNCaP cells with butein (10-30 µM; 48 h) caused a dose-dependent decrease in the protein expression of cyclinsD1 by using immunoblot analysis. Treatment of CWR22Rm1 cells with butein (10-30 µM; 48 h) also caused an inhibition of cyclin D1,suggesting that the effects of butein on prostrate cancer(PCa) cells are not limited for one-cell type.22114764
CCND1cyclin D1595Prostrate CarcinomaCWR22Rm1----LNCaP cells with butein (10-30 µM; 48 h) caused a dose-dependent decrease in the protein expression of cyclinsD1 by using immunoblot analysis. Treatment of CWR22Rm1 cells with butein (10-30 µM; 48 h) also caused an inhibition of cyclin D1,suggesting that the effects of butein on prostrate cancer(PCa) cells are not limited for one-cell type.22114764

 






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