NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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Compound: Butein

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

matrix metallopeptidase 7 (matrilysin, uterine)

Liver Carcinoma

SK-HEP-1

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The gelatin zymography assay indicated that butein inhibited the activity of matrix metalloproteinases 2 (MMP-2). Gelationlytic activity of MMP-2 in the zymogram was inhibited by butein in a dose-dependent manner. Thus, MMP 2 was down-regulated in butein-treated SK-HEP-1 cells.

matrix metallopeptidase 7 (matrilysin, uterine)

Liver Carcinoma

SK-HEP-1

-

-

-

-

Western blotting analysis indicated that butein decreased the level of MMP-7 in SK-HEP-1 cell.

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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.