NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Chebulinic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
GATA1GATA binding protein 12623LeukemiaK-562----In K562 cells only treated with chebulinic acid 50 micromol/L for 72 h, the levels of gamma-globin and PBGD mRNA as well that of mRNA for erythroid transcription factor NF-E2 were obviously decreased, the level of mRNA for GATA-1,another erythroid transcription factor, was slightly reduced, the level of mRNA for GATA-2, a megakaryocytic transcription factor, was obviously induce.14769215
GATA2GATA binding protein 22624LeukemiaK-562----In K562 cells only treated with chebulinic acid 50 micromol/L for 72 h, the levels of gamma-globin and PBGD mRNA as well that of mRNA for erythroid transcription factor NF-E2 were obviously decreased, the level of mRNA for GATA-1,another erythroid transcription factor, was slightly reduced, the level of mRNA for GATA-2, a megakaryocytic transcription factor, was obviously induce.14769215
HBG1hemoglobin, gamma A3047LeukemiaK-562----In K562 cells only treated with chebulinic acid 50 micromol/L for 72 h, the levels of gamma-globin and PBGD mRNA as well that of mRNA for erythroid transcription factor NF-E2 were obviously decreased, the level of mRNA for GATA-1,another erythroid transcription factor, was slightly reduced, the level of mRNA for GATA-2, a megakaryocytic transcription factor, was obviously induce.14769215
HMBShydroxymethylbilane synthase3145LeukemiaK-562----In K562 cells only treated with chebulinic acid 50 micromol/L for 72 h, the levels of gamma-globin and PBGD mRNA as well that of mRNA for erythroid transcription factor NF-E2 were obviously decreased, the level of mRNA for GATA-1,another erythroid transcription factor, was slightly reduced, the level of mRNA for GATA-2, a megakaryocytic transcription factor, was obviously induce.14769215
NFE2nuclear factor (erythroid-derived 2), 45kDa4778LeukemiaK-562----In K562 cells only treated with chebulinic acid 50 micromol/L for 72 h, the levels of gamma-globin and PBGD mRNA as well that of mRNA for erythroid transcription factor NF-E2 were obviously decreased, the level of mRNA for GATA-1,another erythroid transcription factor, was slightly reduced, the level of mRNA for GATA-2, a megakaryocytic transcription factor, was obviously induce.14769215

 






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